Author/Authors :
Deju Ye، نويسنده , , Guanghui Deng، نويسنده , , Wenfeng Liu، نويسنده , , Yu Zhou، نويسنده , , Enguang Feng، نويسنده , , Hualiang Jiang and Helmut Grubmüller، نويسنده , , Hong Liu، نويسنده ,
Abstract :
A simultaneous stereoselective 2-O-deacetylation and 4-amination reaction of peracetylated Neu5Ac 1 has been established with cyclic secondary amines, such as 1-N-Boc-piperazine. Four C2-symmetric and two asymmetric sialic acid dimers with (4→4)-piperazine derivatives linked were synthesized. They may serve as precursors of unnatural polysialic acids.
