Ethylenediamine diacetate (EDDA)-catalyzed one-pot synthesis of tetrahydroquinolines by domino Knoevenagel/hetero Diels–Alder reactions from 1,3-dicarbonyls

This paper describes new and efficient synthetic approaches for biologically interesting tetrahydroquinoline analogues. The key strategies involve the ethylenediamine diacetate-catalyzed cyclization of 1,3-dicarbonyls to aminobenzaldehydes through domino Knoevenagel/hetero Diels–Alder reactions. These reactions provide a rapid route for the synthesis of novel polycycles with the tetrahydroquinoline moiety.