Title of article
Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B
Author/Authors
Takanori Matsumaru، نويسنده , , Toshiaki Sunazuka، نويسنده , , Tomoyasu Hirose، نويسنده , , Aki Ishiyama، نويسنده , , Miyuki Namatame، نويسنده , , Takashi Fukuda، نويسنده , , Hiroshi Tomoda، نويسنده , , Kazuhiko Otoguro، نويسنده , , Satoshi Omura، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
9
From page
7369
To page
7377
Abstract
The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal SN2′ type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma brucei brucei strain GUTat 3.1.
Keywords
Tensyic acid , Total synthesis , Selective esterification , Chirabite-AR , Anti-trypanosomal activity , Formal SN2 reaction
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094386
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