Author/Authors :
Tohru Nagamitsu، نويسنده , , Daisuke Takano، نويسنده , , Miyuki Seki، نويسنده , , Shiho Arima، نويسنده , , Masaki Ohtawa، نويسنده , , Kazuro Shiomi، نويسنده , , Yoshihiro Harigaya، نويسنده , , Satoshi Omura، نويسنده ,
Abstract :
Nafuredin (1) is converted to nafuredin-γ (2) under mild basic conditions and both compounds exhibit the same inhibitory activity and selectivity against NADH-fumarate reductase (complex I). The total synthesis of 2 was achieved by a convergent approach using Stille coupling. The structural elements required for inhibitory activity against NADH-fumarate reductase (complex I) were then investigated by evaluation of nafuredin-γ (2) and its structural analogues.
