Title of article :
Reactions of 1,2-diaza-1,3-dienes with thiol derivatives: a versatile construction of nitrogen/sulfur containing heterocycles
Author/Authors :
Orazio A. Attanasi، نويسنده , , Paolino Filippone، نويسنده , , Samuele Lillini، نويسنده , , Fabio Mantellini، نويسنده , , Simona Nicolini، نويسنده , , Jes?s M. de los Santos، نويسنده , , Roberto Ignacio، نويسنده , , Domitila Aparicio، نويسنده , , Francisco Palacios، نويسنده ,
Abstract :
The synthesis of substituted 2,3-dihydro-1,4-thiazines, fused cycloalkyl-1,4-thiazines, 1,4-benzothiazines and fused cycloalkyl-1,4-benzothiazines by 1,4-addition of 1,2-aminothiols to 1,2-diaza-1,3-dienes bearing carboxylate, carboxamide, or phosphorylated groups and subsequent internal heterocyclization is described. The reaction of carboxylated 1,2-diaza-1,3-butadienes with 2-(butylamino)ethanethiol affords 1,4-thiazinan-3-ones. The solid-phase reaction of polymer-bound 1,2-diaza-1,3-butadienes with 1,2-aminothiols produces 2,3-dihydro-1,4-thiazines and 1,4-benzothiazines.
