Enantioselective alkynylation of aromatic and heteroaromatic aldehydes catalyzed by resin-supported oxazolidine–titanium complexes

Highly enantioselective asymmetric addition of terminal alkynes to various aromatic and heteroaromatic aldehydes catalyzed by the readily available, low-cost, and reusable resin-supported oxazolidine 4 together with Ti(OiPr)4 provides the chiral propargylic alcohols with good to excellent yields (up to 98%) and enantioselectivities (up to 95%). The immobilized catalyst can be recovered and used for five cycles.