Title of article
Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines
Author/Authors
Martin Kuchar، نويسنده , , Radek Pohl، نويسنده , , Blanka Klepet??ov?، نويسنده , , Michal Hocek، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
10
From page
10355
To page
10364
Abstract
Dihydroxylation of 6-vinylpurines with t-BuOOH and OsO4 gave 6-(1,2-dihydroxyethyl)purines 2, while the epoxidation with H2WO4 and t-BuOOH afforded 6-(oxiran-2-yl)purines 3. Oxirane ring-opening reactions of 3 with diverse nucleophiles gave a series of title 6-(1,2-disubstituted ethyl)purine bases and nucleosides, which were tested for cytostatic and antiviral activities.
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094741
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