Author/Authors :
Yoshiyasu Ichikawa، نويسنده , , Kenshi Matsunaga، نويسنده , , Toshiya Masuda، نويسنده , , Hiyoshizo Kotsuki، نويسنده , , Keiji Nakano، نويسنده ,
Abstract :
A new route for the synthesis of the cytotoxic anhydrosphingosine pachastrissamine has been developed. [3.3] Sigmatropic rearrangement of an allyl cyanate was employed to construct the allyl amine moiety in 2 from the chiral C-4 unit 3. Oxidative cleavage of the double bond in 2, followed by THF ring formation furnished the target pachastrissamine.
