Title of article :
Syntheses of sphingomyelin methylene, aza, and sulfur analogues by the versatile olefin cross-metathesis method
Author/Authors :
Tetsuya Yamamoto، نويسنده , , Hiroko Hasegawa، نويسنده , , Sekimi Ishii، نويسنده , , Satoshi Kaji، نويسنده , , Tatsuro Masuyama، نويسنده , , Syuji Harada، نويسنده , , Shigeo Katsumura، نويسنده ,
Abstract :
The syntheses of optically homogeneous sphingomyelin analogues, which possess CH2, NH, and S instead of the phosphate oxygen connecting the phosphocholine head group to the sphingosine backbone, were successfully achieved by employing the olefin cross-metathesis protocol between 1-pentadecene and the amino alcohol parts possessing the suitable building block or functional group for construction of the phosphocholine moiety. In addition, fluorescence-labeled sphingomyelin methylene analogue was also synthesized.
