Title of article
The Ugi reaction with CF3-carbonyl compounds: effective synthesis of α-trifluoromethyl amino acid derivatives
Author/Authors
Anton V. Gulevich، نويسنده , , Nikolay E. Shevchenko، نويسنده , , Elisabeth S. Balenkova، نويسنده , , Gerd-Volker R?schenthaler، نويسنده , , Valentine G. Nenajdenko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
7
From page
11706
To page
11712
Abstract
The Ugi reaction with CF3-carbonyl compounds is described in detail. The method is efficient for the multicomponent preparation of α-trifluoromethyl (Tfm) amino acids, α-Tfm containing dipeptides, and iminodicarboxylic acids. In addition, the first protected CF3-opine derivative was prepared. The scope, limitations, and stereochemistry of the approach are discussed.
Keywords
Ugi reaction , Fluoral , Dipeptides , Opine , Fluorine chemistry
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094902
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