A convenient route to chiral γ-lactones via asymmetric hydrogenation of γ-ketoesters using the RuCl3–BINAP–HCl catalytic system
Author/Authors :
Eugenia V. Starodubtseva، نويسنده , , Olga V. Turova، نويسنده , , Maxim G. Vinogradov، نويسنده , , Lilia S. Gorshkova، نويسنده , , Vladimir A. Ferapontov، نويسنده , , Marina I. Struchkova، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Pages :
5
From page :
11713
To page :
11717
Abstract :
A convenient one-step synthesis of chiral γ-lactones has been performed. The method is based on enantioselective hydrogenation of γ-ketoesters using the RuCl3–BINAP–HCl catalytic system. Chiral γ-lactones (91–99% ee) have been isolated in 57–88% yield.
