Title of article :
Synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions
Author/Authors :
Yanong D. Wang، نويسنده , , Minu Dutia، نويسنده , , M. Brawner Floyd، نويسنده , , Amar S. Prashad، نويسنده , , Dan Berger، نويسنده , , Melissa Lin، نويسنده ,
Abstract :
A regio- and stereoselective synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated coupling reactions was developed. The comparison and optimization of stereoselectivity of the Heck, Stille, and Suzuki reactions of 7-bromo or 7-triflate-3-quinolinecarbonitrile are described. Compound 7 and 10 were potent inhibitors of Src kinase and Raf/Mek activity, respectively.
