Author/Authors :
Jae Hoon Choi، نويسنده , , Madoka Horikawa، نويسنده , , Hiroshi Okumura، نويسنده , , Shinya Kodani، نويسنده , , Kaoru Nagai، نويسنده , , Daisuke Hashizume، نويسنده , , Hiroyuki Koshino، نويسنده , , Hirokazu Kawagishi، نويسنده ,
Abstract :
Two novel compounds, 3-(hydroxymethyl)-4-methylfuran-2(5H)-one (1) and (3R,4S,1′R)-3-(1′-hydroxyethyl)-4-methyldihydrofuran-2(3H)-one (2), were isolated along with two known ones (3 and 4) from an edible mushroom Mycoleptodonoides aitchisonii. The structures of 1–4 were determined by the interpretation of spectroscopic data. Compounds 1–4 showed protective activity against endoplasmic reticulum (ER) stress-dependent cell death.
