Title of article :
New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation
Author/Authors :
Haruhisa Kikuchi، نويسنده , , Tomoko Hoshi، نويسنده , , Minoru Kitayama، نويسنده , , Mizuki Sekiya، نويسنده , , Yasuhiro Katou، نويسنده , , Yasuhiro Ajiro and Kazunori Ueda ، نويسنده , , Yuzuru Kubohara، نويسنده , , Hiroki Sato، نويسنده , , Mitsuaki Shimazu، نويسنده , , Shoichiro Kurata، نويسنده , , Yoshiteru Oshima، نويسنده ,
Abstract :
To date, entomopathogenic fungi have not been extensively examined by natural product chemists. In this study, we isolated novel pyrone diterpene-type compounds, metarhizins A (1) and B (2), from methanol extracts of entomopathogenic fungus, Metarhizium flavoviride. They showed potent and selective antiproliferative activity against both insect and human cancer cell lines. These results indicate that metarhizins A (1) and B (2) can be used as novel lead compounds for anti-cancer agents and probes for cell cycle regulation. To further investigate the structural requirements for this inhibitory activity, we synthesized many metarhizin derivatives and evaluated their antiproliferative activities.
