Author/Authors :
Michael Harding، نويسنده , , Jennifer A. Bodkin، نويسنده , , Fatiah Issa، نويسنده , , Craig A. Hutton، نويسنده , , Anthony C. Willis، نويسنده , , Malcolm D. McLeod، نويسنده ,
Abstract :
The 4-nitrophenyl ether is an efficient directing group in the asymmetric aminohydroxylation reaction of homoallylic ether derivatives. Either regioisomeric product can be obtained with useful levels of enantioselectivity allowing for the short enantioselective synthesis of GABOB and homoserine derivatives. A model based on substrate-catalyst interactions is presented to explain the regio- and enantioselectivity of the aminohydroxylation reactions.
Keywords :
Osmium , Asymmetric catalysis , Regioselective , Amino acid , Asymmetric aminohydroxylation
