Title of article
Synthesis and evaluation of substituted indolizidines as peptidomimetics of RGD tripeptide sequence
Author/Authors
Delphine Halie، نويسنده , , Joëlle Pérard-Viret، نويسنده , , Sylvie Dufour، نويسنده , , Jacques Royer، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
13
From page
1402
To page
1414
Abstract
The synthesis of seven peptidomimetics of RGD is presented. The indolizidine building block was obtained by condensation of allylglycine with dimethoxydihydrofuran followed by an intermolecular cyclization. The bicyclic ring was functionalised with a carboxylic acid and a guanidinium appendage. The seven peptidomimetics were evaluated by cell-adhesion assays.
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095101
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