• Title of article

    Organocatalytic enantioselective formal synthesis of HRV 3C-protease inhibitor (1R,3S)-thysanone

  • Author/Authors

    Rajiv T. Sawant، نويسنده , , Suresh B. Waghmode، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2009
  • Pages
    4
  • From page
    1599
  • To page
    1602
  • Abstract
    A short and efficient organocatalytic enantioselective formal synthesis of HRV 3C-protease inhibitor (1R,3S)-thysanone is achieved in a nine-step with 98.7% enantiomeric excess, by employing l-proline-catalyzed asymmetric α-aminooxylation of aldehyde and Oxa-Pictet–Spengler cyclization as the key steps.
  • Keywords
    Asymmetric ?-aminooxylation , proline , thysanone , pyranonaphthoquinones , Oxa-Pictet–Spengler cyclization
  • Journal title
    Tetrahedron
  • Serial Year
    2009
  • Journal title
    Tetrahedron
  • Record number

    1095125

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1095125