Title of article
Gold(III)-catalyzed direct nucleophilic substitution of propargylic alcohols
Author/Authors
Marie Georgy، نويسنده , , Valérie Boucard، نويسنده , , Olivier Debleds، نويسنده , , Christophe Dal Zotto، نويسنده , , Jean-Marc Campagne، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
9
From page
1758
To page
1766
Abstract
Gold-catalyzed nucleophilic substitution of propargylic alcohols with various nucleophiles (allylsilane, electron-rich aromatics, alcohols, thiols, hydrides, 1,3-dicarbonyl derivatives, sulfonamides) is described under very mild conditions (room temperature in dichloromethane). Preliminary mechanistic investigations suggest a mechanism through a carbocation intermediate. Nucleophilic substitutions on allylic and benzylic alcohols are also described.
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095145
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