Title of article
An efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one
Author/Authors
Pinak M. Chincholkar، نويسنده , , Ajaykumar S. Kale، نويسنده , , Vikas K. Gumaste، نويسنده , , Abdul Rakeeb A.S. Deshmukh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
2605
To page
2609
Abstract
An efficient formal synthesis of S-(+) dapoxetine starting from 3-hydroxy azetidin-2-one is described. The intermediate (S)-3-(dimethyl amino)-3-phenylpropan-1-ol was synthesized in enantiopure form starting with 3-hydroxy azetidin-2-one in seven steps.
Keywords
Enantioselective synthesis , ?-Lactams , azetidin-2-ones , Reduction , Staudinger reaction
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095252
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