Title of article
Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum
Author/Authors
Osamu Muraoka، نويسنده , , Toshio Morikawa، نويسنده , , Yi Zhang، نويسنده , , Kiyofumi Ninomiya، نويسنده , , Seikou Nakamura، نويسنده , , Hisashi Matsuda، نويسنده , , Masayuki Yoshikawa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
7
From page
4142
To page
4148
Abstract
Four novel megastigmanes, neosedumosides I (1), II (2), III (3), and IV (4) were isolated from the whole plant of Sedum sarmentosum (Crassulaceae). Absolute stereostructures of these constituents were determined on the basis of chemical and physicochemical evidence. Among them, 1–3 were found to show lipid accumulation inhibitory activity in HepG2 cells. Furthermore, 2 and 3 were found to also show lipid metabolism-promoting activity.
Keywords
Lipid accumulation inhibitory activity , Lipid metabolism-promoting activity , Crassulaceae , Neosedumoside , megastigmane , Sedum sarmentosum
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095431
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