Title of article :
An effective new access to ethyl 2-[(alkylamino)(cyano)methyl] acrylates: first synthesis of ethyl 3-cyano-2-(hydroxymethyl) acrylate
Author/Authors :
Aïcha Arfaoui، نويسنده , , Hassen Amri، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A regioselective coupling of ethyl 2-(bromomethyl)-3-cyanoacrylate and primary amines is described to give ethyl 2-[(alkylamino)(cyano)methyl] acrylates in good yields. Whereas the conversion of allyl bromide in the presence of TEAF leads to the first synthesis of ethyl 3-cyano-2-(hydroxymethyl) acrylate.
Keywords :
Ethyl 2-(bromomethyl)-3-cyanoacrylate , Regioselectivity , Functionalized allylamines , Ethyl 3-cyano-2-(hydroxymethyl) acrylate , Triethylammonium formate (TEAF)
Journal title :
Tetrahedron
Journal title :
Tetrahedron
