Title of article
An effective new access to ethyl 2-[(alkylamino)(cyano)methyl] acrylates: first synthesis of ethyl 3-cyano-2-(hydroxymethyl) acrylate
Author/Authors
Aïcha Arfaoui، نويسنده , , Hassen Amri، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
4904
To page
4907
Abstract
A regioselective coupling of ethyl 2-(bromomethyl)-3-cyanoacrylate and primary amines is described to give ethyl 2-[(alkylamino)(cyano)methyl] acrylates in good yields. Whereas the conversion of allyl bromide in the presence of TEAF leads to the first synthesis of ethyl 3-cyano-2-(hydroxymethyl) acrylate.
Keywords
Ethyl 2-(bromomethyl)-3-cyanoacrylate , Regioselectivity , Functionalized allylamines , Ethyl 3-cyano-2-(hydroxymethyl) acrylate , Triethylammonium formate (TEAF)
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095524
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