Title of article :
Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization
Author/Authors :
Justin R. Struble، نويسنده , , Jeffrey W. Bode، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic γ-lactam-γ-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic.
Keywords :
?-Chiral amines , Asymmetric catalysis , Chemoselectivity , Heterocycles , Functionalized imines
Journal title :
Tetrahedron
Journal title :
Tetrahedron
