Metathesis cascade strategies (ROM–RCM–CM): a DOS approach to skeletally diverse sultams

The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM–RCM–CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels–Alder (IMDA) reactions undergo metathesis cascades to yield a collection of tricyclic sultams. Additional appendage-based diversity was achieved by utilizing a variety of CM partners.