Author/Authors :
Guohua Chu، نويسنده , , Bertrand Le Bourdonnec، نويسنده , , Minghua Gu، نويسنده , , Christopher T. Saeui، نويسنده , , Roland E. Dolle، نويسنده ,
Abstract :
A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.
