Title of article
Developing an efficient route to the synthesis of nucleoside 1-alkynylphosphonates
Author/Authors
Maïa Meurillon، نويسنده , , Franck Gallier، نويسنده , , Suzanne Peyrottes، نويسنده , , Christian Perigaud، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
8
From page
6039
To page
6046
Abstract
A series of ribonucleoside 1-alkynylphosphonates have been synthesized using a palladium-catalyzed phosphonylation of terminal 1,1-dibromo-1-alkene nucleosidic derivatives and high selectivity for product distribution was observed during this step. Both nucleosidic and osidic pathways were explored and the corresponding optimization study is reported herein.
Keywords
Nucleotide analogue , 1-Alkynylphosphonate , Sugar phosphonate
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097358
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