Title of article :
Efficient preparation of N′,N″-1H-isoindole-1,3-diylidenedicarbohydrazides via 1,1,3-trichloro-1H-isoindole, and their characterization
Author/Authors :
Olga V. Hordiyenko، نويسنده , , Igor V. Rudenko، نويسنده , , Angelina V. Biitseva، نويسنده , , Aleksandr V. Turov، نويسنده , , Axelle Arrault، نويسنده , , Nicolas Brosse، نويسنده , , Olivier Fabre، نويسنده , , Brigitte Jamart-Grégoire، نويسنده , , Roman I. Zubatyuk، نويسنده , , Oleg V. Shishkin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
N′,N″-1H-Isoindole-1,3-diylidenedialkyl(aryl,heteroaryl)carbohydrazides were prepared in good yields via 1,1,3-trichloro-1H-isoindole, which was shown to be a versatile reagent for their synthesis. Tautomeric structure and conformational behaviour of dicarbohydrazides in solid state as well as in solution have been studied by X-ray crystallography, NMR spectroscopy and quantum calculations. The dependence of Z/E amide-type isomerism upon steric effects and solvent polarity is discussed.
Keywords :
1H-Isoindole , Carbohydrazides , NMR spectroscopy , X-ray diffraction , Structure elucidation
Journal title :
Tetrahedron
Journal title :
Tetrahedron
