Title of article
Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches
Author/Authors
Huan Wang، نويسنده , , Hayao Matsuhashi، نويسنده , , Brian D. Doan، نويسنده , , Steven N. Goodman، نويسنده , , Xi Ouyang، نويسنده , , William M. Clark Jr.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
13
From page
6291
To page
6303
Abstract
Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5–C6 disconnection by ring closing metathesis to construct an azepane ring and are amenable to large-scale manufacturing.
Keywords
Oxazolidinone cleavage , RCM , Curtius , Epoxide opening
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097453
Link To Document