Title of article :
Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol
Author/Authors :
Béranger Duthion، نويسنده , , Thomas-Xavier Métro، نويسنده , , Domingo Gomez Pardo، نويسنده , , Janine Cossy، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol.
Keywords :
rearrangement , 1 , 2-amino alcohols , Aziridinium , (S)-Toliprolol , (S)-Propanolol
Journal title :
Tetrahedron
Journal title :
Tetrahedron
