Title of article
A convenient synthesis of 2-substituted indoles by the reaction of 2-(chloromethyl)phenyl isocyanides with organolithiums
Author/Authors
Kazuhiro Kobayashi، نويسنده , , Daisuke Iitsuka، نويسنده , , Shuhei Fukamachi، نويسنده , , Hisatoshi Konishi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
7523
To page
7526
Abstract
The reaction of 2-(chloromethyl)phenyl isocyanides, readily available by dehydration of the respective N-[2-(chloromethyl)phenyl]formamides, with organolithiums produced 2-substituted indoles in satisfactory yields through addition of organolithiums to the isocyano carbon followed by intramolecular substitution reaction of the resulting imidoyl anion intermediates.
Keywords
Indoles , Intramolecular substitution , organolithiums , isocyanides , Imidoyl anion
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097697
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