Title of article
Synthesis of boranoate, selenoate, and thioate analogs of AZTp4A and Ap4A
Author/Authors
Qianwei Han، نويسنده , , Stefan G. Sarafianos، نويسنده , , Eddy Arnold، نويسنده , , Michael A. Parniak، نويسنده , , Barbara L. Gaffney، نويسنده , , Roger A. Jones، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
7915
To page
7920
Abstract
We report efficient, one-flask procedures for the synthesis of a family of 14 analogs of AZTp4A and Ap4A containing BH3, S, or Se, along with two bisphosphonate analogs of Ap4A. These compounds should slow unwanted enzymatic hydrolysis and have the potential to create unique binding interactions in biochemical and structural studies of the excision reaction responsible for resistance of HIV-1 to AZT, as well as assist in drug design.
Keywords
Boranoate , AZT , HIV-RT , Dinucleoside tetraphosphate
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097740
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