Title of article
Reagent-controlled diastereoselective synthesis of (2S,3R)- and (2R,3R)-2,3-diaminobutanoic acid derivatives using proline-catalyzed α-hydrazination reaction
Author/Authors
Kazuishi Makino، نويسنده , , Sayaka Kubota، نويسنده , , Sousuke Hara، نويسنده , , Masaru Sakaguchi، نويسنده , , Akinari Hamajima، نويسنده , , Yasumasa Hamada، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
9468
To page
9473
Abstract
(2S,3R)- and (2R,3R)-2,3-Diaminobutanoic acid (Dab) derivatives were efficiently synthesized from Cbz-(R)-alanine using the proline-catalyzed diastereoselective α-hydrazination reaction and the SmI2-promoted reductive cleavage of the N–N bond as the key steps.
Keywords
proline , Organocatalyst , Asymmetric synthesis , ?-Hydrazination , Diaminobutanoic acid , Alanine
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1099226
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