Author/Authors :
Carsten Schultz-Fademrecht، نويسنده , , Olaf Kinzel، نويسنده , , Istv?n E. Mark?، نويسنده , , Tomas Pospisil، نويسنده , , Silvia Pesci، نويسنده , , Michael Rowley، نويسنده , , Philip Jones، نويسنده ,
Abstract :
An efficient and general synthesis of homochiral α-amino substituted bromo-heteroaromatics B using a diastereoselective 1,2-addition has been developed. The obtained heteroaromatic intermediates allow for a rapid two-dimensional exploration of a new series of histone deacetylase inhibitors, through Suzuki–Miyaura cross-coupling reactions for the introduction of a second aromatic element, followed by global deprotection and derivatization of the amino group.
