Title of article :
The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids
Author/Authors :
John E. Mangette، نويسنده , , Matthew R. Johnson، نويسنده , , Van-Duc Le، نويسنده , , Rajesh A. Shenoy، نويسنده , , W. Howard Roark، نويسنده , , Michael Stier، نويسنده , , Thomas Belliotti، نويسنده , , Thomas Capiris، نويسنده , , Peter R. Guzzo، نويسنده ,
Abstract :
Optically active α-amino 4H-[1,2,4]oxadiazol-5-ones (oxadiazolones) were prepared from optically active α-amino acids in five synthetic steps. The oxadiazolone moiety serves as a bioisosteric replacement for the carboxylic acid. Incorporation of an α-amino oxadiazolone into a representative dipeptide mimic is described.
Keywords :
Optically active , ?-amino acid , Bioisostere , Oxadiazolone
