Title of article
Cyclopropylation of arylamines at the 2-position with cyclopropylmagnesium carbenoids
Author/Authors
Yukie Yamada، نويسنده , , Mirai Mizuno، نويسنده , , Shinobu Nagamoto، نويسنده , , Tsuyoshi Satoh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
11
From page
10025
To page
10035
Abstract
Direct cyclopropylation of arylamines at the 2-position with 1-chlorocyclopropyl phenyl sulfoxides was achieved. The reaction of N-lithio arylamines with cyclopropylmagnesium carbenoids, which are generated from 1-chlorocyclopropyl phenyl sulfoxides with i-PrMgCl via the sulfoxide–magnesium exchange reaction, is the key of this procedure. This method offers an unprecedented way for the synthesis of arylamines having a cyclopropane ring at the 2-position directly from arylamines.
Keywords
Cyclopropylation of arylamine , Magnesium carbenoid , 2-Cyclopropylated arylamine , Cyclopropylation , Cyclopropylmagnesium carbenoid
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1100294
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