Author/Authors :
Ermes Vanotti، نويسنده , , Marina Caldarelli، نويسنده , , Teresa Disingrini، نويسنده , , Marcella Nesi، نويسنده , , Marco Tat?، نويسنده , , Paola Vianello، نويسنده , , Maria Menichincheri، نويسنده ,
Abstract :
The regioselective synthesis of halogenated aminopyrimidinyl-pyrroles as useful scaffolds for the preparation of diversified selective kinase inhibitors is described. The chemistry is simple and mostly based on the use of N-halosuccinimides under mild reaction conditions but the regioselectivity observed is partially unexpected.
Keywords :
Kinase inhibitors , Pyrimidine , Pyrrole , N-halosuccinimide , Halogenation
