Title of article :
An easy access to unsymmetrically substituted 4,4′-bi-1,2,3-triazoles
Author/Authors :
Vito Fiandanese، نويسنده , , Daniela Bottalico، نويسنده , , Giuseppe Marchese، نويسنده , , Angela Punzi، نويسنده , , Francesca Capuzzolo، نويسنده ,
Abstract :
A convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsymmetrically substituted 4,4′-bi-1,2,3-triazole derivatives has been devised starting from easily available 1-trimethylsilyl-1,3-butadiyne. The starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl halides, or into novel 4,4′-bi-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides.
