Title of article
Bis-Lewis acids-catalyzed highly diastereoselective one-pot reductive dehydroxylation of chiral N,O-acetals
Author/Authors
Li-Jiao Jiang، نويسنده , , Bo Teng، نويسنده , , Jian-Feng Zheng، نويسنده , , Jian Liang Ye، نويسنده , , Pei Qiang Huang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
172
To page
175
Abstract
A one-pot and highly diastereoselective method for the reductive dehydroxylation of three classes of heterocyclic N,O-acetals with general structure 4 is reported. The method features a ‘two in one’ concept, namely, by synergetic action of two complementary Lewis acids (BF·OEt2 and TiCl4), the bicyclic or tricyclic oxazololactams 5 were formed in situ and reductively cleaved to give the corresponding lactams 6 in a high-yielding and highly diastereoselective manner.
Keywords
Diastereoselectivity , Lewis acids , Asymmetric synthesis , Heterocycles , Cooperative effects
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100411
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