Copper-Free Sonogashira coupling in water with an amphiphilic resin-supported palladium complex

The palladium-catalyzed coupling reaction of aryl halides with terminal alkynes, the Sonogashira coupling, took place in water under copper-free conditions by use of an amphiphilic polystyrene-poly(ethylene glycol) (PS–PEG) resin-supported palladium–phosphine complex to give the corresponding aryl-substituted alkynes in high yields. The PS–PEG resin-supported palladium catalyst was recovered by simple filtration and reused four times without any loss of catalytic activity.