Title of article
De novo synthesis of teleocidin B analogs
Author/Authors
Jun Pu، نويسنده , , Kangwen Deng، نويسنده , , John Butera، نويسنده , , Michael Chlenov، نويسنده , , Adam Gilbert، نويسنده , , Mike Kagan، نويسنده , , James Mattes، نويسنده , , Lynn Resnick، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
10
From page
1963
To page
1972
Abstract
Teleocidin B analogs have been synthesized in 24 steps and 1.9% overall yield. The key steps include aromatic Claisen rearrangement, intramolecular Heck reaction of a tetra-substituted alkene, and ruthenium (II) catalyzed indole cyclization. Teleocidin and the new analogs promote cell spreading on fibroblast cells that were treated with amino-Nogo, an inhibitor of cell spreading.
Keywords
intramolecular Heck reaction , Claisen rearrangement , Ruthenium catalyzed indole cyclization , Teleocidin B
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100623
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