Title of article
Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions
Author/Authors
Loreto Legerén، نويسنده , , Domingo Dom?nguez، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
2718
To page
2722
Abstract
The efficiency of a cyclodehydration reaction leading to benzodiazepinones is markedly improved by N-methylation of the amide link connecting the nucleophile and the electrophile, which is attributed to its favouring both the more reactive E-rotamer and the exit of the leaving group.
Keywords
pyrrolobenzodiazepine , proline , Benzodiazepinone , Amidoalcohol , Cyclodehydration
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100717
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