Highly regioselective lithiation of inter-ring carbon of bis(thien-2yl)methane: a general meso-elaboration protocol

Bis(thien-2yl)methane is regioselectively lithiated at the inter-ring methylene carbon using dimsyl anion in THF at 0 °C; quenching with appropriate electrophile furnishes meso-elaborated derivatives, exclusively with synthetic advantage.