Amide-directed arylation of sp3 C–H bonds using Pd(II) and Pd(0) catalysts

Protocols to effect β-arylation of sp3 C–H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC6F5 directing group. These reactions provide an unprecedented means to functionalize sp3 C–H bonds in aliphatic carboxylic acid-derived substrates.