Title of article
Highly enantioselective Michael addition of aldehydes to nitroolefins catalyzed by primary amine thiourea organocatalysts
Author/Authors
Jia-Rong Chen، نويسنده , , Quan Zou، نويسنده , , Liang Fu، نويسنده , , Fan-Ren Chang، نويسنده , , Hsiu-Fen Tan، نويسنده , , Wen-Jing Xiao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
6
From page
5367
To page
5372
Abstract
Asymmetric Michael addition reactions of aldehydes to nitroolefins have been successfully initiated by a series of primary amine thiourea bifunctional catalysts, with high enantioselectivities (90–98% ee) and excellent yields (80–96%). The privileged quinine scaffold was found to be essential to the reaction efficiency and enantioselectivity.
Keywords
Organocatalysis , Amine thiourea , Michael addition , Nitroolefin
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101037
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