Title of article
Syntheses of differentially protected isocoumarins
Author/Authors
Andrew N. Lowell، نويسنده , , Philip D. Wall، نويسنده , , Stephen P. Waters، نويسنده , , Marisa C. Kozlowski، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
10
From page
5573
To page
5582
Abstract
Syntheses of an isocoumarin subunit suitable for the completion of purpuromycin are outlined. Specifically, work targeting an orthogonally protected isocoumarin (eventually 12% yield over 12 steps) and an improved synthesis of a symmetrically protected isocoumarin (18% over 10 steps) are described. A new modification for selective catechol protection as mediated by potassium bicarbonate is also presented along with insights into oxidative and reductive functionalization of isocoumarins.
Keywords
Isocoumarin , Rubromycin , Selective oxidation , Orthogonal protection
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101059
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