Author/Authors :
Neil P. Grimster، نويسنده , , Donna A.A. Wilton، نويسنده , , Louis K.M. Chan، نويسنده , , Christopher R.A Godfrey، نويسنده , , Clive Green، نويسنده , , Dafydd R. Owen، نويسنده , , Matthew J. Gaunt، نويسنده ,
Abstract :
A new tandem catalysis strategy that transforms alkyne derivatives to (E)-enol-equivalents followed by stereoselective anti-selective aldol coupling or syn-selective [3,3]-rearrangement transformations is reported. The mechanism is thought to proceed through an interchanging series of Lewis acid and Brønsted acid catalyzed reactions via the intermediacy of a ketiminum ion species.
Keywords :
Stereoselective aldol , enolate , Stereoselective Sigmatropic rearrangement , alkyne , Tandem catalysis
