Title of article :
First Stereoselective Synthesis of a Pro-Pro E-Alkene Dipeptide Isostere
Author/Authors :
Harms، Klaus نويسنده , , Bandur، Nina G. نويسنده , , Koert، Ulrich نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A stereoselective synthesis of a proline-proline E-alkene isostere is described. Starting from N-Boc-L-proline the new stereocenter is generated by diastereoselective alkenylation and subsequent Ireland-Claisen rearrangement. The relative configuration of the double bond and the new generated stereocenter were determined by X-ray crystallography.
Keywords :
proline , dipeptide isostere , selective alkenylation , Ireland-Claisen rearrangement , E-alkene , Felkin-Anh
