Title of article
Synthesis of epoxy and aziridino malonyl peptidomimetics
Author/Authors
Stefania Fioravanti، نويسنده , , Simona Gasbarri، نويسنده , , Lucio Pellacani، نويسنده , , Federico Ramadori، نويسنده , , Paolo A. Tardella، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
9401
To page
9404
Abstract
Short malonyl dehydro peptides have been epoxidized using H2O2/Na2WO4 dihydrate. The obtained diastereomeric epoxides were separated by HPLC and successfully tested in the ring opening reaction with N-Boc l-cysteine methyl ester, to indicate their electrophilic behavior. Moreover, by a simple two-step reaction, the epoxy malonyl peptides can be converted into the corresponding aziridino malonyl peptides.
Keywords
Epoxides , Sodium tungstate , Retro-peptides , Aziridines
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102715
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