Title of article :
Efficient and Selective Deuteration of Phenylalanine Derivatives Catalyzed by Pd/C
Author/Authors :
Sajiki، Hironao نويسنده , , Hirota، Kosaku نويسنده , , Maegawa، Tomohiro نويسنده , , Akashi، Akira نويسنده , , Esaki، Hiroyoshi نويسنده , , Aoki، Fumiyo نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A facile and efficient deuteration method of phenylalanine derivatives using a Pd/C-H2-D2O system has been developed. Selective deuteration at the (beta)position of phenylalanine derivatives occurred using Pd/C as a catalyst with high deuterium efficiency without racemization at 110 °C. Also, the (alpha)position was deuterated at higher temperature.
Keywords :
PALLADIUM , catalysis , amino acids , deuteration , regioselectivity
