A One-Pot Non-Aldol-Aldol Vinylogous Mukaiyama Aldol Tandem Sequence for the Rapid Construction of Polyketide Frameworks

The rapid assembly of polyketide segments remains one central task in the field of natural product synthesis. Besides the stereoselective assembly of carbon frameworks functional group transformations and protecting group manipulations have to be optimized in order to streamline organic synthesis. The activated aldehyde derived from Jung’s non aldol-aldol method serves as an intermediate for the subsequent vinylogous Mukaiyama aldol reaction.