Author/Authors :
Emma Sierecki، نويسنده , , Gauthier Errasti، نويسنده , , Thierry Martens، نويسنده , , Jacques Royer، نويسنده ,
Abstract :
We describe the diastereoselective α-allylation of various amines using an anodic oxidation-amidoalkylation sequence. Especially, we found that an acyclic amine, diethylamine, can be allylated with an excellent diastereoselectivity, as high as 94/6. Following our simple protocol, functionalized piperidine, pyrrolidine, morpholine, and tetrahydroisoquinoline were also obtained with moderate to good diastereomeric excesses and in good to excellent yields.
